TISSUE ENGINEERING BIOREACTORS: POTENTIAL APPLICATIONS AND SCALE UP STRATEGY

Bioreactors in tissue engineering.

A bioreactor can be defined as a device that uses mechanical means to influence biological processes. In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This chapter dis...

The Role of Bioreactors in Tissue Engineering for Musculoskeletal Applications

Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a biocompatible scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell d...

Bioreactors for Liver Tissue Engineering

A cute liver failure (ALF) patients have a high risk of mortality. The elective treatment for ALF still is orthotopic liver transplantation. Donor organ scarcity and the associated high costs make transplantation possible for only about one third of the patients on the transplantation waiting list. Engineering a biological liver substitute is an interesting alternative to the traditional ALF th...

IV.3. Bioreactors in tissue engineering.

OrbShake Bioreactors for Mammalian Cell Cultures : Engineering and Scale - up THÈSE

Most of the biopharmaceuticals nowadays are produced by animal cells. The worldwide demand for a specific group of biopharmaceuticals, the monoclonal antibodies (mAbs), has significantly increased this last decade. The mAbs are used as therapeutics in particular against cancer and autoimmune disorders. Most of the mAbs are produced as recombinant proteins by mammalian cells which ensure human-l...